SPONSOR EVENTS
Platinum Sponsor Presentations
Throughout the Workshops and Scientific Sessions, you will have the opportunity to join a presentation hosted by one of our Platinum Sponsors. Check back to this page often for updates.
Bruker
Sponsor Studio (Workshop) 4.1
Tuesday, June 22 Paris | 3:00 - 3:45 p.m. Evaluation of Post-Acute COVID-19 Syndrome using NMR Spectroscopy and Mass Spectrometry
Employing multiple high field NMR spectroscopic and Mass Spectrometric Platforms, the ANPC provides an integrative analytical and systems framework for exploring the aetiopathogenesis of disease using principles that are scalable and translatable to any pathological condition. In the battle against SARS CoV-2 and COVID-19 we are faced with a dynamic and adaptable enemy and the ongoing challenge of unravelling the complex immunopathological drivers of the acute and persistent effects of the disease. The ANPC has examined patient biofluids from a variety of international sources over 15 months to create new diagnostic and prognostic modelling approaches for disease detection, severity prediction and long-term follow up studies. NMR and mass spectrometric data on blood plasma and urine show that COVID-19 causes multiple organ damage that are partially independent of the primary respiratory features. These multi-organ system involvements contribute to the level of morbidity shown in individual patients and lead to multiple levels of clinical actionability in the hospital environment and for studying patient recovery trajectories. A key concern now is the international medico-economic burden of “Post-Acute COVID-19 Syndrome” (PACS) and the problem of identifying long-term effects of the disease at the biochemical level to monitor and mitigate long term effects in individuals.
Waters Corporation
Sponsor Studio (Workshop) 4.2
Tuesday, June 22 Paris | 3:50 - 4:35 p.m.Are we now ready to realise the full potential of ion mobility in metabolomics?
Ion mobility mass spectrometry offers benefits to complex sample analysis such as an increase to system peak capacity, the separation of certain isomeric compounds and the ability to measure the collisional cross-sectional area of ions. With the wide popularity of machine-learning approaches and a growing body of empirically measured data, we are now in the position to generate predicted CCS values at scale and speed. In this workshop we will discuss how these values could impact metabolomics methods now and in the future.
Agilent Technologies
Sponsor Studio (Workshop) 5.1
Tuesday, June 22 New York | 1:00 - 1:45 p.m. Development of targeted lipidomics platform and application to population cohorts to research cardiometabolic risk
Agilent’s innovations in targeted LC/MS approaches have driven the field of lipidomics. Owing to their isomeric and isobaric nature, the diversity of the lipidome is inherently difficult to capture in a comprehensive manner. Therefore, unprecedented sensitivity, speed, reliable data precision at very low dwell times and high dynamic range are all crucial MS attributes for lipidomics research. First, we will describe innovative technologies integrated into our 6495C LC/TQ system along with specific targeted lipidomics workflows to achieve both comprehensiveness and throughput without compromise. Secondly, we will introduce our guest speakers Dr. Peter Meikle and Dr. Kevin Hyunh from the Baker Institute, as they report a high-throughput plasma lipidomic assay measuring 750 lipid species (capturing both polar and nonpolar lipids) from 44 classes in 15 minutes. They have applied this approach to multiple studies of up to 10,000 deidentified plasma samples, and here report the utilisation of the lipidomics readout to generate risk scores for cardiometabolic disease. Relative lipid concentrations were calculated using a series of non-physiological internal standards. An extension of this approach in human brain samples identified over 1,300 unique lipid species and this method can be systematically adapted for the lipidome in other biological samples in large cohorts.
European Network of Fourier-Transform Ion-Cyclotron-Resonance Mass Spectrometry Centers
Sponsor Studio (Workshop) 5.2
Tuesday, June 22 New York | 1:50 - 2:35 p.m.Metabolomics in the 21st century and beyond
Imagine a mass spectrometer exceeding 10 million resolution and a mass accuracy in the ppb range, across a wide m/z interval. Imagine you could analyse complex samples, containing tens to hundreds of thousands of metabolites in a few minutes, without chromatographic separation, in a few minutes and fragment all ions without precursor selection for 2D-MS and mapping the spatial distribution of metabolites. Enter the world of Fourier-Transform Ion-Cyclotron Resonance Mass Spectrometry (FT-ICR-MS), that offers the highest figures of merit and versatility to reveal the metabolome universe in a truly unprecedent way.FT-ICR-MS is rare and requires a high level of training and experience, European researchers created a Network of Fourier-Transform Ion-Cyclotron-Resonance Mass Spectrometry Centers, funded by the EU-H2020 grant agreement 731077. This network aims to provide access to world-class FT-ICR-MS centers, build a community of FT-ICR-MS scientists, open access to data and open-source software and strengthen the FT-ICR-MS application fields. Several applications where the benefits of the unique and unmatched analytical characteristics of FT-ICR-MS in metabolomics will be showcased, as well as how to access our research centres and enrol in our advanced training program in FT-ICR-MS. Challenge us with your metabolomic problems that you never imagined could be solved!
Biocrates Life Sciences
Scientific Session 3.3
Wednesday, June 23 Paris | 12:55 - 1:15 p.m.
Microbiome research has dramatically reshaped our understanding of how microbes impact a multitude of (patho-)physiological processes in the host and effect metabolic disease developments in diabetes, cancer, cardiovascular disease, and neurological disorders. Metabolomics allows the investigation of microbial metabolic activities and thus is the ideal technology to assess functional nutrition-microbiota-host crosstalk. Here, we discuss the application of a developed standardized targeted metabolomics platform (MxP® Quant 500 kit) fulfilling uniquely the FAIR principle compliance (i.e. Findability, Accessibility, Interoperability, Reusability) for the quantification of up to 860 endogenous and microbiota-derived metabolites and metabolism indicator sums and ratios.Recent advancements of metabolomics for disease commonalities, specificities and trends in microbiome research will be discussed. You will be presented with an overview of key metabolic pathways and bioactive molecules e.g. enterosynes relevant for the gut-liver-brain axis linking intestinal bacteria to distant organs, including choline metabolism, tryptophan metabolism, and bile acid metabolism. Based on several high-impact literature-based examples, you will learn how the gut microbiome impacts pathophysiological processes, disease development, and response to drug treatment with a focus on cancer and neurological disorders and how to use the value of data quality, comparability, and translation across studies.
SCIEX
Scientific Session 4.2
Wednesday, June 23 Paris | 4:00 - 4:20 p.m.
Most MS/MS-based metabolomics experiments rely on collision induced dissociation (CID) for inducing fragmentation. This presentation will showcase a new ion fragmentation paradigm with enhanced sensitivity for enabling richer, more comprehensive data and structural metabolite information with the new innovative, accurate mass spectrometry. Dr. Hankemeier will share his perspective on how this technology will deliver more complete libraries for more accurate metabolomic identification, offering researchers the capability to make more informed decisions and unambiguous conclusions.
Metabolon
Scientific Session 5.3
Wednesday, June 23 New York | 2:25 - 2:45 p.m.
Metabolomics Sample Collection in the Wild
The study of disease in human subjects often requires the analysis of a large numbers of samples due to the diversity of the human population including our genetic profiles, diets, and lifestyles. Investigators must therefore recruit individuals who are willing and able to visit a clinic for sample collection. This itself can reduce recruitment but also limits investigations to those individuals who are mobile and within proximity to the sampling locations. In addition, certain sample types have associated challenges and limitations such as the increased sampling, processing and cold storage requirements for blood and feces, of interest in microbiome research, being not amenable to on-demand collection. Given the increased demand for large human population studies and the desire to expand the population base that can be reached, sample collection methods that permit collection of samples away from the clinic would address many of these challenges and reduce costs. Furthermore, collection of samples away from the clinic requires the stabilization technology to preserve the integrity of samples during transit from collection location to the lab. The underlying biological information must be maintained in the absence of a cold-storage chain of custody. Over the last several years, Metabolon has been investigating and validating the use of various “in the wild” blood and fecal collection strategies for use in global metabolomics studies. While many different collection options were piloted, full validation was conducted on dried blood spots using Whatman 903 cards and feces using DNA Genotek’s OMNImet-GUTTM fecal collection tube. Both sample collection strategies were fully validated and included precision, stability, fidelity and biological testing. The results and findings from the validation activities will be presented.
Thermo Fisher Scientific
Virtual Happy Hour
Wednesday, June 23 New York | 2:45 - 3:15 p.m.There’s nothing trivial about QAQC in Metabolomics
It is always happy hour somewhere in the world. We invite you to bring your beverage of choice to this lively session as we challenge your knowledge of QAQC in metabolomics applications through trivia. Keeping us on track will be a core panel of field experts as they share firsthand experiences and insight. Let us see how much you know!
Host: Amanda Souza, Metabolomics Program Manager, Thermo Fisher Scientific
Thermo Fisher Scientific
Scientific Session 11.2
Thursday, June 24 New York | 2:00 - 2:20 p.m.
Metabolomics, the investigation of small molecules present in a biological system, finds application in diverse biomedical and industrial research. In large-scale applications, targeted profiling of metabolites is employed as it provides confident measurements for known compounds. However, sometimes the observed phenotype cannot be explained by only monitoring a subset of metabolites. Instead, comprehensive metabolome coverage is needed to provide knowledge about underlying biochemical mechanisms. Chemical diversity of the metabolome necessitates data collection with multiple ionization modes for a complete picture. High resolution accurate mass Orbitrap technology with polarity switching enables unbiased compound detection for the accurate analysis of target metabolites and the retro-mining of data to discover unexpected biochemical mechanisms. Here, we apply the targeted profiling workflow utilizing a Thermo Scientific™ Orbitrap Exploris™ 120 mass spectrometer for the nutrient evaluation of fetal bovine serum (FBS) as supplemental material in cell culture applications.Routinely used as growth supplement in in vitro cell culture, FBS contains vital components like amino acids, sugars, and lipids essential for cell growth and proliferation. To assess potential variation of metabolite levels detected in this supplemental material, serum was commercially sourced from multiple vendors across several geographical regions using different processing protocols. High resolution full scan acquisition with fast polarity switching enabled quantitation in both positive and negative polarities for target metabolites in the Metabolomics QReSS™ standard kit and simultaneous detection of unknown compounds for increased metabolome coverage. Metabolic differences for target analytes and putative compounds were distinctively observed in serum extracts between processing protocols, but also regional sourcing. Metabolite associations further revealed differences for pathway-related metabolites. In summary, comprehensive metabolic profiling was achieved using the Orbitrap Exploris™ 120 mass spectrometer with enabled polarity switching for confident measurements of target metabolites while simultaneously allowing for the confident identification of other relevant compounds in commercially sourced FBS samples.
Thermo Fisher Scientific
Virtual Happy Hour
Thursday, June 24 New York | 2:45 - 3:15 p.m.Innovations in Metabolomics: 3 Lightning Talks to Inspire and Intrigue
Hold on to your hats because in this Happy Hour we will take a whirlwind tour of new technologies to support metabolomics applications from Thermo Fisher Scientific. Listen in to see if our presenters can rise to the challenge of 8-minutes or less to tell you about new Thermo Scientific™ products including a modified Orbitrap Tribrid™ mass spectrometer, Compound Discoverer™ software, and the Orbitrap Exploris™ 240 GC mass spectrometer.
Host: Amanda Souza, Metabolomics Program Manager, Thermo Fisher Scientific
Presenters:
Aaron Robitaille, Senior Product Marketing Manager, Thermo Fisher Scientific
Ralf Tautenhahn, Platform Manager Metabolomics Software, Thermo Fisher Scientific
Dominic Roberts, Product Marketing Manager GC Orbitrap, Thermo Fisher Scientific
METABOLOMICS SOCIETY | metabolomicssociety.org